PalpMark is being developed to guide minimal invasive surgical procedures in the thoracic- and abdominal region.
Surgeons often rely on tactile feedback when identifying the surgical target. As a rule of thumb, tumors under 10mm is identifiable using palpation whereas smaller tumors and non-solid targets, such as ground glass opacities, are not.
PalpMark shall aid surgeons to identify invisible and impalpable thoracic- and abdominal tumors during surgery by creating a palpable and radiopaque target surrogate. PalpMark can also be found using visual identification due to color.
In the lung indication, PalpMark shall be applied into peripheral lung tissue adjacent to the target during electromagnetic navigation bronchoscopy (ENB) procedures. PalpMark is liquid during the application procedure, which enable application of large volumes with use of thin needles. After injection of the PalpMark liquid into soft tissue, efflux of miniscule ethanol leads to formation of a blue/violet, radiopaque and palpable PalpMark marker in-vivo.
PalpMark has been successfully tested in preclinical studies and has the potential to aid surgeons to identify invisible and impalpable thoracic- and abdominal tumors during surgery. Nanovi is currently finalizing pre-clinical documentation for a clinical trial application in the lung indication with expected patient enrollment mid-2018.
Early stage lung cancer
Early stage diagnosis of lung cancer is of paramount importance in order to ensure successful treatment and improve overall survival. Wide-range implantation of lung cancer screening programs in asymptomatic persons with an average or high risk for lung cancer have led to an increase in the number of early stage patients with small pulmonary lesions or ground glass opacities.
Minimal invasive surgery is the preferred surgical method to resect small pulmonary lesions, however, intraoperative localization of small pulmonary lesions has shown to be challenging as these are both invisible and impalpable during surgery. PalpMark has the potential to has to aid surgeons to localize these invisible and impalpable thoracic targets.