Features & benefits

The main features of BioXmark^® are:

• Liquid

• Sticky and soft iodine based marker

• Non metallic

Feature: Liquid

Claim	Benefit
Injectable with thin needles up to 25G	Less risk for procedure related complications such as bleeding and pneumothorax
Adaptable marker sizes	Meeting different needs for marker sizing. Adaptable also during implantation
Implantation of multiple markers in the same procedure	Less risk of procedure related complications
Applicable in soft tissue including organs in the thoracic, pelvic and abdominal regions	One marker to cover a wide range of cancers such as lung, esophagus, rectum and bladder cancer
Implantable with flexible scopes	Implantation with flexible scopes gives accessibility across multiple cancer locations
Implantable with standard equipment	No need for additional training nor for special equipment
Fast and easy implantation procedure	Potential to save time

Feature: Sticky and soft iodine based marker

Claim	Benefit
Biocompatible	Has an acceptable biological safety profile
Adaptive to surrounding tissue	Low risk of tissue damage
Positionally stable during treatment planning, treatment and follow-up	Enables precise target localization during treatment planning, treatment and follow-up
Visible on ultrasound	Ultrasound guided implantation ensures higher precision of marker placement and verification of marker location
Radiopaque, visible on X-ray (2D X-ray, fluoroscopy, CT, CBCT)	Visibility on X-ray enables high precision in treatment planning, treatment and follow-up Fluoroscopy guided implantation ensures higher precision during marker placement and verification of marker location
Visible on MRI	MR visibility enables high precision during treatment planning, treatment and follow-up Fusion of CT and MR images enables high precision during treatment planning, treatment and follow-up
Visible for minimum 2 months	Remains visible during treatment and follow-up

Feature: Non metallic

Claim	Benefit
Low dose perturbation	Compatible with proton radiation therapy
Low level of artifacts	The low level of artifacts supports: - Precise treatment planning and image guided treatment - Fusion of CT and MR images
MR safe	No marker displacement by MR fields

These 17 claims translate into the following main benefits of BioXmark^®:

• Customizable implantation
• Positional stability and visibility
• Photon and proton radiation compatibility